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Start Date:

December 2020

End Date:



48 months




GA Number: 101016167

Title: Connecting European Cohorts to Increase Common and Effective Response to SARS-CoV-2 Pandemic.

Design: Population based, prospective and retrospective cohort study.

Background: ORCHESTRA provides an innovative approach to learn from the pandemic SARS-CoV-2 crisis and form recommendations to improve further management of COVID-19 and be prepared for the possible future pandemic waves. 

The ORCHESTRA project aims to respond to this need through the creation of a new pan-European cohort built on existing and new large-scale population cohorts in European (France, Germany, Spain, Italy, Belgium, Romania, Netherlands, Luxemburg, and Slovakia) and non-European countries (India, Perú, Ecuador, Colombia, Venezuela, Argentina, Brazil, Congo and Gabon). 

The knowledge gleaned from the study of these cohorts will inform European strategies with regards to:

  • effective protection of fragile populations in Europe (e.g children, pregnant women, the elderly, solid organ transplant recipients, Alzheimer patients, oncological patients, Parkinson disease patients, patients with mental illness, HIV positive subjects)

  • reduction of the risks for frontline health care staff

  • longer-term consequences of COVID-19 on the health and well-being of individuals;

  • vaccination response

  • impact of environmental factors, socio-economic determinants, lifestyle and confinement measures on the spread of COVID-19

Update: In August 2023 the project was given a 12 month, no-cost extension.


UNIVR, University of Verona - ITALY (Coordinator) 

UNIBO, Alma Mater Studiorum - Università di Bologna - ITALY

INSERM, Institut National de la Santè et de la Recherche Medicale - FRANCE

SAS, Servicio Andaluz de Salud - SPAIN 

CINECA Consorzio Interuniversitario - ITALY

LIH, Luxembourg Institute of Health - LUXEMBOURG

AP-HP, Assistance Publique Hopitaux de Paris - FRANCE

RER-ASSR, Regione Emilia Romagna - ITALY

ISGLOBAL, Fundacion Privada Instituto de Salud Global Barcelona - SPAIN

LMU, Ludwig-Maximilians- Universitaet Muenchen - GERMANY

UANTWERPEN, Universiteit Antwerpen - BELGIUM

HMGU, Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh - GERMANY

UHC, Klinikum der Universitaet zu Koeln - GERMANY


USTUTT, Universitaet Stuttgart - GERMANY

CERMEL, Centre de Recherches Medicales de Lambaréné - GABON

RAPH BB, Regionalny Urad Verejneho Zdravotnictva so Sidlom v Banskej Bystrici - SLOVAKIA

CHARITÉ - Universitaetsmedizin Berlin - GERMANY

UMCG, Academisch Ziekenhuis Groningen - NETHERLANDS

CINES, Centre Informatique National De L'enseignement Superieur - FRANCE

UNIOVI, Universidad de Oviedo - SPAIN

UBA, Universidad de Buenos Aires- ARGENTINA

INSP, Institutul National de Sanatate Publica - ROMANIA

UKHD, Universitatsklinikum Heidelberg - GERMANY

REG VEN, Regione del Veneto - ITALY

FCRM, Fondation Congolaise pour la Recherche Medicale - CONGO 

International third parties 

THSTI, Translational Health Science and Technology Institute, Faridabad, Haryana – INDIA

CBCI, Catholics Bishops Conference of India, Society for Medical Education, Bangalore – INDIA

UNIFESP, Escola Paulista de Medicina - Universidade Federal de São Paulo - BRAZIL




How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2

Clinical Microbiology and Infection


Using machine learning to predict antibody response to SARS-CoV-2 vaccination in solid organ transplant recipients: the multicentre ORCHESTRA cohort

Clinical Microbiology and Infection


Perpetual observational studies: new strategies to support efficient implementation of observational studies and randomized trials in infectious diseases



Association of patients' epidemiological characteristics and comorbidities with severity and related mortality risk of SARS-CoV-2 infection: results of an umbrella systematic review and meta-analysis

The Lancet Regional Health-Europe


Challenges of data sharing in European Covid-19 projects: A learning opportunity for advancing pandemic preparedness and response

NPJ Digital Medicine


Harmonization and standardization of data for a pan-European cohort on SARS- CoV-2 pandemic

Journal of Infection


Determinants of persistence of symptoms and impact on physical and mental wellbeing in Long COVID: A prospective cohort study



Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

Infectious Diseases and Therapy


Diagnostic accuracy of a rapid SARS-CoV-2 Antigen Test among people experiencing homelessness: a prospective cohort and implementation study



Exploratory data on the clinical efficacy of monoclonal antibodies against SARS-CoV-2 Omicron variant of concern



Usefulness and limitations of Anti-S IgG Assay in detecting previous SARS-CoV-2 breakthrough infection in fully vaccinated healthcare workers



SARS-CoV-2 breakthrough infections: incidence and risk factors in a large European multicentric cohort of health workers



Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort

eClinical Medicine



Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort

The Journal of clinical investigation


Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments

Hematological Oncology


Predictors of clinical evolution of SARS-CoV-2 infection in hematological patients: A systematic review and meta-analysis



Clinical impact of monoclonal antibodies in the treatment of high-risk patients with SARS-CoV-2 breakthrough infections: the ORCHESTRA prospective cohort study

European journal of clinical microbiology & infectious diseases


Clinical efficacy of different monoclonal antibody regimens among non-hospitalised patients with mild to moderate COVID-19 at high risk for disease progression: a prospective cohort study

Clinical Microbiology and Infection


Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis

ID-CARE Participants

Evelina Tacconelli


Elena Carrara

Clinical Researcher, MD

Alessia Savoldi

Medical Doctor

Anna Giulia Salvadori

ID Resident

Filippo Cioli Puviani

ID Resident

Lorenzo Tavernaro

ID Resident

Francesco Luca

ID Resident

Fabiana Arieti

Clinical Research Assistant & Project Manager

Ruth Joanna Davis

Project Officer

Angela Musmeci

Project Assistant

Anna Maria Azzini

Lecturer and Consultant Physician

Fulvia Mazzaferri

Medical Doctor

Maria Diletta Pezzani

Medical Doctor

Chiara Zanchi

ID Resident

Chiara Konishi de Toffoli

ID Resident

Rebecca Scardellato

ID Resident

Concetta Sciammarella

Lab Technician

Gaia Maccarrone

Clinical Research Assistant

Stefania Vitali

Project Manager

Elisa Gentilotti

Clinical Researcher, MD

Pasquale De Nardo

Medical Doctor

Francesca Gianolla

ID Resident

Ilaria Dalla Vecchia

ID Resident

Andrea Sartori

ID Resident

Hermes Salvatore Dall'O'

ID Recident

Lorenzo Canziani

Clinical Research Manager

Maela Tebon

Clinical Research Assistant

Alessia Mirandola

Project and Personnel Manager

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