Title: World Health Organization Bacterial Priority Pathogens’ List

Background: The objective of this analysis is to create an update of the 2017 Bacterial Priority Pathogens’ List (BPPL), with the aim of providing an essential guide for planning, implementing, monitoring research and development (R&D) in the field of new antibiotics to contrast antimicrobial resistance, considering policy-making and public health perspective, in order to direct future interventions. 

The project consists of a review of the available data, published in the scientific literature and/or included in surveillance reports, aimed at defining levels of documented evidence for each of the 8 pre-established criteria (mortality, incidence, resistance trend, non-fatal burden of disease, transmissibility, treatability, preventability, and pipeline) related to 23 resistant pathogens-drug combinations. 

For the 2023 prioritization exercise, the final ranking will be computed through a Multi-Component Decisional Analysis that will combine expert opinions to assign a relative weight to each criterion. A stratification into three tiers (critical, medium, and high priority) will be done.