Title: Stewardship Antibiotica VErona.

Design: Hospital-wide multifaceted Antimicrobial Stewardship Intervention. Monocentric, quasi-experimental, non-randomized, Interrupted Time Series, open-label study.

Primary Objective: Improving the quality of care through decreasing the rate of inappropriate antibiotic prescription and the rates of infections caused by antibiotic-resistant organisms. Measuring the effect of the Antimicrobial Stewardship Interventions (ASI) implementation on:

• variation in antibiotic consumption.

• prevalence of Carbapenem-Resistant Enterobacteriaceae (CRE) bacteremia and C.difficile infections.

• patient-safety metrics.

Secondary Objective: Analyzing the individual and socio-contextual determinants influencing prescribing behaviours, barriers and facilitators for ASI implementation.