Title: Stewardship Antibiotica VErona.

Design: Hospital-wide multifaceted Antimicrobial Stewardship Intervention. Monocentric, quasi-experimental, non-randomized, Interrupted Time Series, open-label study.

Registration Number: n.a.

Primary Objective: Improving the quality of care through decreasing the rate of inappropriate antibiotic prescription and the rates of infections caused by antibiotic-resistant organisms. Measuring the effect of the Antimicrobial Stewardship Interventions (ASI) implementation on:

• variation in antibiotic consumption.

• prevalence of Carbapenem-Resistant Enterobacteriaceae (CRE) bacteremia and C.difficile infections.

• patient-safety metrics.

Secondary Objective(s):

Analyzing the individual and socio-contextual determinants influencing prescribing behaviours, barriers and facilitators for ASI implementation.

Interested in collaboration? Contact: Marcella Sibani marcella.sibani@univr.it  save.veneto@aovr.it

Publications:

Donisi V et al. Emotional, cognitive and social factors of antimicrobial prescribing: can antimicrobial stewardship intervention be effective without addressing psycho-social factors? J Antimicrob Chemother. 2019 Oct 1;74(10):2844-2847. doi: 10.1093/jac/dkz308. PMID: 31299072. https://pubmed.ncbi.nlm.nih.gov/31299072/

Carrara E et al. SAVE: Stewardship Antibiotica VErona: a new model of stewardship to reduce antimicrobial overuse in a setting with high levels of antimicrobial resistance rates Abstract 7559, 30th ECCMID, April 2020 https://markterfolg.de/ESCMID/Abstractbook2020.pdf

Carrara E et al. Assessment of local individual and contextual determinants of antibiotic prescribing to inform tailored antimicrobial stewardship intervention.

Poster 2075, 29th ECCMID, April 2019, Amsterdam, Netherlands https://www.escmid.org/escmid_publications/escmid_elibrary/material/?mid=68730