EU-RESPONSE

Start Date

July 2020

Duration

60 months

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Title: European DisCoVeRy for Solidarity: An Adaptive Pandemic and Emerging Infection Platform Trial – EUropean RESearch and Preparedness netwOrk for pandemics and emerging iNfectious diseaSEs


Design: European, multi-centre, randomised, parallel group, phase III, adaptive platform trial on Investigational Medicinal Products (IMPs) in hospitalized adult patients with moderate or severe COVID-19.


Registration Number: n.a.


Primary Objective:

  • PART A, moderate COVID-19 disease: to determine the causal effect of IMPs against standard of care on occurrence of disease progression in hospitalized patients with moderate COVID-19

  • PART B, severe COVID-19 disease: to determine the causal effect of IMPs against standard of care on occurrence of death in hospitalized patients with severe or critical COVID-19

Secondary Objective(s):

  • to compare the efficacy of IMPs against standard of care on other core clinical endpoints

  • to compare IMPs against standard of care in hospitalized patients with COVID-19 on major serious adverse events

  • to compare IMPs against standard of care in hospitalized patients with COVID-19 on patient reported outcomes

Interested in collaboration? Contact Fulvia Mazzaferri, fulvia.mazzaferri@aovr.veneto.it


Publications: Submitted

Partners

INSERM (Coordinator)
Hospices Civils de Lyon,
Arbeitsgemeinschaft medikamentöse Tumortherapie,
Assistance Publique - Hopitaux de Paris,
Attikon University Hospital,
Centre Hospitalier du Luxembourg,
Centro Hospitalar Universitario Sao Jao,
Charles University,
Cliniques Universitaires de Bruxelles-Erasme,
European Clinical Research Infrastructure Network,
Hacettepe University School of Medicine,
Inserm Transfert,
Institut National De La Sante Et De La Recherche Medicale,
Medical University of Lodz,
Norwegian Institute of Public Health,
Oslo University Hospital,
Pavol Jozef Safarik University in Kosice,
Servicio Madrileño de Salud,
University College of Cork,
University of Bern,
University of Szeged,
University of Verona

ID-CARE

  • Elda Righi

  • Evelina Tacconelli

  • Fulvia Mazzaferri