GA Number: 101015736

Title: European DisCoVeRy for Solidarity: An Adaptive Pandemic and Emerging Infection Platform Trial – EUropean RESearch and Preparedness netwOrk for pandemics and emerging iNfectious diseaSEs

Design: European, multi-centre, randomised, parallel group, phase III, adaptive platform trial on Investigational Medicinal Products (IMPs) in hospitalized adult patients with moderate or severe COVID-19.

Primary Objectives:

• PART A, moderate COVID-19 disease: to determine the causal effect of IMPs against standard of care on occurrence of disease progression in hospitalized patients with moderate COVID-19

• PART B, severe COVID-19 disease: to determine the causal effect of IMPs against standard of care on occurrence of death in hospitalized patients with severe or critical COVID-19

Secondary Objectives:

• to compare the efficacy of IMPs against standard of care on other core clinical endpoints

• to compare IMPs against standard of care in hospitalized patients with COVID-19 on major serious adverse events

• to compare IMPs against standard of care in hospitalized patients with COVID-19 on patient reported outcomes