Title: Combination therapy to treat sepsis due to carbapenem-resistant bacteria in adult and paediatric population: evidence and common practice

Design: Cross sectional survey, systematic reviews and network meta-analyses

Primary objective: Specific objectives are:

• to investigate the prescription habits and attitudes among clinicians usually dealing with CR-GNB

• to comprehensively summarize the evidence on the available antibiotic options for the treatment of sepsis due to CR-GNB, including in vitro and in vivo data, and clinical studies

Bringing together clinical practice and data from literature, the final aim is to point out the major gaps in knowledge in order to drive the development of future studies on the most promising treatment schemes within the GARDP projects.