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The role of combination therapy in the treatment of severe infections caused by carbapenem resistant gram-negatives: a systematic review of clinical studies

Savoldi, Alessia; Carrara, Elena; Piddock, Laura J V; Franceschi, Francois; Ellis, Sally; Chiamenti, Margherita; Bragantini, Damiano; Righi, Elda; Tacconelli, Evelina

BMC Infectious Diseases volume 21, Article number: 545 (2021)

Effective treatment of sepsis due to carbapenem-resistant Gram-negative bacteria (CR-GNB) remains a challenge for clinicians worldwide. In recent years, the combination of antibiotics has become the preferred treatment strategy for CR-GNB infection. However, robust evidence to support this approach is lacking. This systematic review aimed at critically evaluating all available antibiotic options for CR-GNB sepsis with particular focus on combination.

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