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ESCMID guidelines for the management of the infection control measures to reduce transmission of multidrug-resistant Gram-negative bacteria in hospitalized patients

E Tacconelli, M A Cataldo, S J Dancer, G De Angelis, M Falcone, U Frank,  G Kahlmeter, A Pan, N Petrosillo, J Rodríguez-Baño, N Singh, M  Venditti, D S Yokoe, B Cookson, European Society of Clinical  Microbiology.

Healthcare-associated infections due to multidrug-resistant Gram-negative bacteria (MDR-GNB) are a leading cause of morbidity and mortality worldwide. These evidence-based guidelines have been produced after a systematic review of published studies on infection prevention and control interventions aimed at reducing the transmission of MDR-GNB. The recommendations are stratified by type of infection prevention and control intervention and species of MDR-GNB and are presented in the form of 'basic' practices, recommended for all acute care facilities, and 'additional special approaches' to be considered when there is still clinical and/or epidemiological and/or molecular evidence of ongoing transmission, despite the application of the basic measures. The level of evidence for and strength of each recommendation, were defined according to the GRADE approach.

Keywords: Acinetobacter; Burkholderia; Enterobacteriaceae; Pseudomonas; Stenotrophomonas; extended-spectrum β-lactamase; guideline; infection control; multidrug-resistant Gram-negative; outbreak.

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