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Title: An international randomised trial of additional treatments for COVID-19 in hospitalised patients who are receiving the local standard of care.

Design: Adaptive, multiarm, controlled randomized clinical trial.

Primary Objective: to provide reliable estimates about any effects of the anti-viral treatments considered in the study on in-hospital mortality in moderate and in severe COVID-19.

Secondary Objective(s): 

  • to assess any effects of anti-viral treatments on hospitalisation length, need for ventilation or for transfer to intensive care

  • to identify any serious adverse reactions.

Originally, hydroxychloroquine, interferon (β1a), lopinavir/ritonavir and Remdesivir were selected as study drugs. After interim analysis, the protocol was amended and three study drugs originally selected (hydroxychloroquine, interferon (β1a), lopinavir/ritonavir) were stopped due to futility. 

The screening of several molecules is still ongoing to identify new possible study drugs.


University of Verona (Coordinator) 

AOU Città della Salute e Scienza, Torino

AOU Policlinico Università di Palermo

ASL Pescara

ASST Cremona

ASST Fatebenefratelli Sacco

ASST Monza

ASST Santi Paolo e Carlo, Milano

ASST Valtellina e Alto Lario

AULSS 9 Scaligera

Ospedale G. Fracastoro - San Bonifacio (VR)

AULSS 9, Distretto 4 - Villafranca (VR)

Azienda Ospedaliera Ospedali Riuniti Marche Nord

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Italy

Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore

INMI Lazzaro Spallanzani

Ospedale Cardinal Massaia, Asti

Ospedale Goretti, Latina

Ospedale Policlinico San Martino

Policlinico Univeristario Mater Domini Catanzaro

Policlinico di S. Orsola, Bologna

Spedali Civili di Brescia

Università della Campania

Università di Bologna

Università di Milano


New England journal of medicine


Repurposed antiviral drugs for Covid-19 - Interim WHO Solidarity trial results

ID-CARE Participants

Evelina Tacconelli


Pasquale De Nardo

Medical Doctor

Maria Diletta Pezzani

Medical Doctor

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