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BIOSTEPS

Start Date

December 01, 2019

Duration

12 months

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Title: Antibiotic stewardship program (ASP) in pancreatic surgery: a multicenter time series analysis


Design: Interrupted time series analysis


Registration Number: 2389 CESC VR_RO


Primary Objective: To evaluate the intervention of an antimicrobial stewardship program and a patient-tailored antibiotic prophylaxis to reduce the occurrence of SSI until 30th day after surgery in patients undergoing pancreatic surgery


Secondary Objective: To evaluate the intervention of an antimicrobial stewardship program to reduce the inappropriate use of key antibiotics, such as piperacillin/tazobactam and carbapenems, administered for prophylaxis or treatment of SSI; to evaluate the intervention of an antimicrobial stewardship program to reduce the treatment costs.


Interested in collaboration?: Contact: annamaria.azzini@univr.it


Publications:

1.       Matteo De Pastena, Salvatore Paiella, Giovanni Marchegiani, Giuseppe Malleo, Debora Ciprani, Clizia Gasparini, Erica Secchettin, Roberto Salvia, Claudio Bassi. Postoperative infections represent a major determinant of outcome after pancreaticoduodenectomy: Results from a high-volume center. Surgery,2017;162(4):792-801


2.       Zhi Ven Fong, , Mc Millan MT, Marchegiani G, Sahora K, Malleo G, de Pastena M, Loehrer AP, Lee GC, Ferrone CR, Chang DC, Hutter MH, Drebin JA, Bassi C, Lillemoe KD, Vollmer CM, Fernandez-del Castillo C. Discordance between perioperative antibiotic prophylaxis and wound infection cultures in patients undergoing pancreaticoduodenectomy. JAMA Surg 2016;151(5):432-9


3.       Matteo De Pastena, Salvatore Paiella, Anna M. Azzini, Giovanni Marchegiani, Giuseppe Malleo, Debora Ciprani, Annarita Mazzariol, Erica Secchettin, Deborah Bonamini, Clizia Gasparini, Ercole Concia, Claudio Bassi, Roberto Salvia. Preoperative surveillance rectal swab is associated with an increased risk of infectious complications in pancreaticoduodenectomy and directs antimicrobial prophylaxis: an antibiotic stewardship strategy? HPB,2018;20(6):555-562

Partners

University of Verona, Unit of General and Pancreatic Surgery (Coordinator)
Ospedale Careggi, Firenze,
Università Campus Biomedico-Roma,
Università degli studi di Firenze, Italia,
Università degli studi di Verona,

ID-CARE

  • Anna Maria Azzini

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