Title: Antibiotic stewardship program (ASP) in pancreatic surgery: a multicenter time series analysis

Design: Interrupted time series analysis

Registration Number: 2389 CESC VR_RO

Primary Objective: To evaluate the intervention of an antimicrobial stewardship program and a patient-tailored antibiotic prophylaxis to reduce the occurrence of SSI until 30th day after surgery in patients undergoing pancreatic surgery

Secondary Objective: To evaluate the intervention of an antimicrobial stewardship program to reduce the inappropriate use of key antibiotics, such as piperacillin/tazobactam and carbapenems, administered for prophylaxis or treatment of SSI; to evaluate the intervention of an antimicrobial stewardship program to reduce the treatment costs.

Interested in collaboration?: Contact: annamaria.azzini@univr.it

Publications:

1.       Matteo De Pastena, Salvatore Paiella, Giovanni Marchegiani, Giuseppe Malleo, Debora Ciprani, Clizia Gasparini, Erica Secchettin, Roberto Salvia, Claudio Bassi. Postoperative infections represent a major determinant of outcome after pancreaticoduodenectomy: Results from a high-volume center. Surgery,2017;162(4):792-801

2.       Zhi Ven Fong, , Mc Millan MT, Marchegiani G, Sahora K, Malleo G, de Pastena M, Loehrer AP, Lee GC, Ferrone CR, Chang DC, Hutter MH, Drebin JA, Bassi C, Lillemoe KD, Vollmer CM, Fernandez-del Castillo C. Discordance between perioperative antibiotic prophylaxis and wound infection cultures in patients undergoing pancreaticoduodenectomy. JAMA Surg 2016;151(5):432-9

3.       Matteo De Pastena, Salvatore Paiella, Anna M. Azzini, Giovanni Marchegiani, Giuseppe Malleo, Debora Ciprani, Annarita Mazzariol, Erica Secchettin, Deborah Bonamini, Clizia Gasparini, Ercole Concia, Claudio Bassi, Roberto Salvia. Preoperative surveillance rectal swab is associated with an increased risk of infectious complications in pancreaticoduodenectomy and directs antimicrobial prophylaxis: an antibiotic stewardship strategy? HPB,2018;20(6):555-562