31/8/20

Cytomegalovirus-Induced Gastrointestinal Bleeding and Pancreatitis Complicating Severe Covid-19 Pneumonia: A Paradigmatic Case

Marchi G, Vianello A, Crisafulli E, Maroccia A, Crinò SF, Pecori S, Zamboni GA, Mazzaferri F, Tacconelli E, Girelli D.

Mediterr J Hematol Infect Dis. 2020 Sep 1;12(1):e2020060. doi: 10.4084/MJHID.2020.060, 09/2020.

COVID-19 is a new pandemic disease whose pathophysiology and clinical  description are still not completely defined. Besides respiratory  symptoms and fever, gastrointestinal (GI) symptoms (including especially  anorexia, diarrhea, and abdominal pain) represent the most frequent  clinical manifestations. Emerging data point out that severe SARS-CoV-2  infection causes an immune dysregulation, which in turn may favor other  infections. Here we describe a patient with severe COVID-19 pneumonia  who developed in the resolving phase abdominal pain associated with  cytomegalovirus (CMV)-induced duodenitis with bleeding and pancreatitis.  A high level of suspicion toward multiple infections, including CMV,  should be maintained in COVID-19 patients with heterogeneous clinical  manifestations.