COMBACTE-MAGNET Epi-Net

Start Date

Januray 2015

Duration

72 months

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Title:

COMBACTE-MAGNET Epidemiology Network


Design: n.a.


Registration number: 115737-4


Primary Objective: Up-to-date surveillance platform integrating data from humans and animals and providing information on prevalence and incidence of AMR and HAI, AMR Outbreaks and Emerging resistances to newly approved antibiotics from epidemiological studies and surveillance systems in Europe.


Secondary Objective:

•             Implementation of frameworks for semi-automation of procedures for surveillance of HAIs.

•             Building networks of healthcare centres sharing epidemiological data to receive statistical model-supported individualised feedback on interventions to reduce setting-specific AMR rates.

•             Develop a consensus program to contribute to the homogenization of the approach on current and future epidemiologic surveillance strategies in Europe.

•             Development of standardised decision-support models, capable of defining the thresholds in resistance data for various infectious disease syndromes and changing empirical antibiotic treatment protocols accordingly.

•             Analysis of burden and outcomes of infections due to multidrug resistant organisms to inform Public Health Action.


Interested in collaboration? Contact: Maria Diletta Pezzani

Mariadiletta.pezzani@univr.it


Publications:

van Rooden SM, Tacconelli E, Pujol M, Gomila A, Kluytmans JAJW, Romme J, Moen G, Couvé-Deacon E, Bataille C, Rodríguez Baño J, Lanz J, van Mourik MSM. A framework to develop semi-automated surveillance of surgical site infections: An international multicenter study. Infection Control & Hospital Epidemiology. 2019 Dec 30:1-8.

https://doi.org/10.1017/ice.2019.321


Babu Rajendran N, Mutters NT, Marasca G, Conti M, Sifakis F, Vuong C, Voss A, Rodríguez-Baño J, Tacconelli E. Mandatory surveillance and outbreaks reporting of the WHO priority pathogens for research & Discovery of new antibiotics in European countries. Clinical Microbiology and Infection.2019 Dec 5. pii: S1198-743X(19)30620-2.

https://doi.org/10.1016/j.cmi.2019.11.020


Savoldi A, Carrara E, Gladstone BP, Azzini AM, Goepel S, Tacconelli E. Gross national income and antibiotic resistance in invasive isolates: analysis of the top-ranked antibiotic-resistant bacteria on the 2017 WHO priority list. Journal of Antimicrobial Chemotherapy, Volume 74, Issue 12, December 2019, Pages 3619–3625.

https://doi.org/10.1093/jac/dkz381


Saris K, Meis JF, Rodríguez-Baño J, Tacconelli E, van de Belt TH, Voss A. Does Online Search Behavior Coincide with Candida auris Cases? An Exploratory Study.J. Fungi 2019, 5(2), 44. https://doi.org/10.3390/jof5020044


van de Belt TH, van Stockum PT, Engelen LJLPG, Lancee J, Schrijver R, Rodríguez-Baño J, Tacconelli E, Saris K, van Gelder MMHJ, Voss A. Social media posts and online search behaviour as early-warning system for MRSA outbreaks. Antimicrob Resist Infect Control. 2018 May 30;7:69.

https://doi.org/10.1186/s13756-018-0359-4


Tacconelli E, Sifakis F, Harbarth S, Schrijver R, van Mourik M, Voss A, Sharland M, Babu Rajendran N, Rodríguez-Baño J, on behalf of the EPI-Net COMBACTE-MAGNET Group. Surveillance for control of antimicrobial resistance. Lancet Infectious Diseases. March 2018.

http://dx.doi.org/10.1016/S1473-3099(17)30485-1


Schrijver R, Stijntjes M, Rodríguez-Baño J, Tacconelli E, Rajendran NB, Voss A. A review of antimicrobial resistance surveillance programmes in livestock and meat thereof in Europe with a focus on antimicrobial resistance patterns in humans. Clin Microbiol Infect. September 2017.

https://doi.org/10.1016/j.cmi.2017.09.013


Núñez-Núñez M, Navarro MD, Palomo V, Rajendran NB, Del Toro MD, Voss A, Sharland M, Sifakis F, Tacconelli E, Rodríguez-Baño J; EPI-Net, Combacte-Magnet and EUCIC Group for SUSPIRE. The methodology of surveillance for antimicrobial resistance and healthcare-associated infections in Europe (SUSPIRE): a systematic review of publicly available information. Clin Microbiol Infect. July 2017.

https://doi.org/10.1016/j.cmi.2017.07.014


Núñez-Núñez M, Navarro MD, Gkolia P, Babu Rajendran N, Del Toro MD, Voss A, Sharland M, Sifakis F, Tacconelli E, Rodríguez-Baño J; and Members of the EPI-NET group on behalf of COMBACTE-MAGNET Consortium. Surveillance Systems from Public Health Institutions and Scientific Societies for Antimicrobial Resistance and Healthcare-Associated Infections in Europe (SUSPIRE): protocol for a systematic review. BMJ Open. March 2017.

https://doi.org/10.1136/bmjopen-2016-014538


Babu Rajendran N, Gladstone BP, Rodríguez-Baño J, Sifakis F, Voss A, Carmeli Y, Burkert FR, Gkolia P, Tacconelli E. EpideMiology and control measures of outBreaks due to Antibiotic-Resistant orGanisms in EurOpe (EMBARGO): a systematic review protocol. BMJ Open. January 2017.

https://doi.org/10.1136/bmjopen-2016-013634


A high quality network of epidemiologic surveillance experts and stakeholders in Europe to map current systems; to define methodological challenge, and develop research strategy for epidemiological studies; to pursue consensus for best-practices and support research and development for new, effective antibiotics.

Partners

University of Verona (Coordinator)
AiCuris Anti-infective Cures GmbH,
Astra-Zeneca, Basilea Pharmaceutica International,
Centre Hospitalier de LIMOGES,
Eberhard Karls Universität Tuebingen,
Fondazione PENTA (PENTA),
GlaxoSmithKline Research and Development Ltd,
Institut Català de la Salut - Hospital Universitari de Bellvitge,
Sanofi U.S.,
Servicio Andaluz de Salud,
Stichting Katholieke Universiteit / Radboud University Nijmegen Medical Centre,
University Medical Center Utrecht (UMCU),
University of Geneve

ID-CARE

  • Anna Gorska

  • Evelina Tacconelli

  • Fabiana Arieti

  • Gloria Santoro

  • Liliana Galia

  • Maela Tebon

  • Maria Diletta Pezzani

  • Monica Compri