Title: Systematic literature review of the burden and outcomes of infections due to multidrug-resistant organisms in Europe Design: Systematic review 

Primary Objective: A systematic review on the burden and outcomes of infections due to multidrug resistant organisms (MDRO) to provide estimations of the burden of some key infections and their outcomes caused by the target MDROs. Crude and infection-attributable mortality and length of hospital stay (overall and in intensive care units). Mortality will be collected as defined in each study, but the primary intention is to analyse in-hospital, 14-day, 30-day and 90-day mortalities. In addition, length of stay will be collected as defined in the studies.